
Bright, grassy, citrusy, and intensely fresh, lemongrass essential oil has one of the most distinctive fragrances in aromatherapy. Although its sharp lemon scent may suggest a citrus fruit, lemongrass is actually a tall tropical grass. The aromatic oil is typically steam-distilled from its leaves and contains high concentrations of citral, a fragrant mixture dominated by the compounds geranial and neral.
The oil is popular in diffuser blends, soaps, massage products, natural perfumes, insect-repellent formulations, and household fragrance recipes. Researchers have also investigated lemongrass for antimicrobial, antifungal, anti-inflammatory, and other biological activities.
Much of that research comes from laboratory or preclinical studies, so it should not be interpreted as proof that a homemade lemongrass preparation can treat infections or inflammatory diseases. A recent randomized clinical trial has also explored inhaled lemongrass aroma for dental anxiety, with promising preliminary results.
For everyday aromatherapy, this tropical grass is most useful for its extraordinarily fresh fragrance and its ability to bring a vivid lemon-herbal character to blends without using a citrus peel oil.
๐ฟ What Is Lemongrass?
The species most commonly associated with aromatherapy is:
Cymbopogon citratus
It belongs to the Poaceae familyโthe enormous botanical family that includes familiar grasses, wheat, rice, corn, bamboo, and many other plants.
Unlike a small lawn grass, lemongrass grows in substantial clumps with long, narrow leaves that can reach impressive heights.
According to Kew’s Plants of the World Online, Cymbopogon citratus is native to southern India and Sri Lanka and is now cultivated or naturalized throughout many tropical regions.
The aromatic leaves have long been used in cooking, traditional herbal preparations, fragrance, and essential oil production.
โก Lemongrass at a Glance
| Feature | Lemongrass |
|---|---|
| Botanical name | Cymbopogon citratus |
| Plant family | Poaceae |
| Plant part used | Leaves and aerial parts |
| Typical extraction | Steam or hydrodistillation |
| Aroma | Lemon-like, grassy, fresh, herbal |
| Major constituents | Geranial and neral |
| Combined aroma compound | Citral |
| Common uses | Diffusion, perfume, massage, soaps, home fragrance |
| Blends well with | Lemon, lavender, geranium, ginger, coriander, cedarwood |
| Aroma strength | Strong |
| Topical use | Careful dilution recommended |
| Main caution | Citral-rich oil can irritate or sensitize skin |
๐ Why Does Lemongrass Smell Like Lemon?
Lemongrass does not contain lemons, but both plants produce some similar aromatic molecules.
The characteristic lemon-like scent of lemongrass comes primarily from citral.
Citral is not one single molecule. It is a mixture of two closely related compounds:
- Geranial
- Neral
Geranial is sometimes called alpha-citral, while neral may be called beta-citral.
Together, they create the strong lemon fragrance associated with lemongrass.
A published chemical analysis of Cymbopogon citratus oil found approximately 42% geranial and 32% neral, although percentages vary among individual oils.
๐ฑ What Does Lemongrass Smell Like?
The fragrance is sharper and more herbal than ordinary lemon peel oil.
It may smell:
- Citrusy
- Grassy
- Green
- Fresh
- Sharp
- Slightly sweet
- Herbal
- Earthy
Lemon essential oil smells more like freshly grated citrus peel.
Lemongrass has a distinct green quality that makes it smell more like lemon combined with freshly cut grass.
Its strength also means a small amount can dominate a blend.
๐ Lemongrass vs. Lemon Essential Oil
Despite their similar names and aromas, these oils come from completely different plants.
Lemongrass
Botanical name:
Cymbopogon citratus
Plant family:
Poaceae
Plant part:
Leaves
Typical extraction:
Steam distillation
Lemon
Botanical name:
Citrus ร limon
Plant family:
Rutaceae
Plant part:
Fruit peel
Typical extraction:
Cold expression or steam distillation
Lemon peel oil is generally dominated by limonene.
Lemongrass is typically dominated by citral.
They can be used together, but they are not interchangeable.
๐ฟ Lemongrass vs. Citronella
Lemongrass and citronella are more closely related than lemon and lemongrass.
Both belong to the genus Cymbopogon.
Citronella oils are commonly produced from species such as:
- Cymbopogon nardus
- Cymbopogon winterianus
Lemongrass commonly comes from Cymbopogon citratus.
Their chemical compositions and fragrances overlap but are not identical.
Citronella generally has a sharper, more recognizably insect-repellent aroma, while lemongrass often smells more strongly lemon-like.
๐ฟ What About East Indian Lemongrass?
Another aromatic grass commonly called lemongrass is:
Cymbopogon flexuosus
It is often known as East Indian lemongrass.
C. citratus and C. flexuosus both produce citral-rich aromatic oils, but they are different botanical species.
Check the Latin name when purchasing an oil rather than relying solely on the word “lemongrass.”
For this guide, the primary focus is Cymbopogon citratus.
๐งช What Is in Lemongrass Oil?
Chemical composition varies according to geography, plant genetics, harvest stage, growing conditions, and extraction method.
Common constituents include:
- Geranial
- Neral
- Myrcene
- Geraniol
- Beta-pinene
- Limonene
- Other monoterpenes
Geranial and neral generally account for a substantial portion of the total oil.
Together, these citral components contribute not only to the fragrance but also to many of the biological activities being investigated in laboratory research.
๐จ Fresh Lemongrass Diffuser Blend
Lemongrass is powerful, so it usually works best alongside softer oils.
Try:
- 2 drops lemongrass
- 3 drops lavender
- 3 drops sweet orange
The orange adds sweetness while lavender softens the sharper grassy qualities.
Use the blend according to your diffuser manufacturer’s instructions.
๐ Lemon & Lemongrass Blend
For an especially bright citrus aroma:
- 2 drops lemongrass
- 3 drops lemon
- 2 drops lavender
Although both main ingredients smell lemony, their differences create a surprisingly layered fragrance.
Lemon contributes fresh peel while lemongrass supplies green herbal depth.
๐ฟ Fresh Herbal Blend
For a clean botanical aroma:
- 2 drops lemongrass
- 3 drops lavender
- 2 drops rosemary
This works particularly well in kitchens, home offices, or daytime living spaces.
The result is fresh without smelling like a conventional sweet citrus fragrance.
๐บ Lemongrass and Geranium Blend
Geranium is an excellent companion for lemongrass.
Try:
- 2 drops lemongrass
- 2 drops geranium
- 3 drops bergamot
Geranium adds rosy-green floral notes while bergamot makes the overall combination brighter and more sophisticated.
๐ถ๏ธ Lemongrass and Ginger Blend
For a warm citrus-spice combination:
- 2 drops lemongrass
- 2 drops ginger
- 3 drops sweet orange
- 1 drop frankincense
Ginger enhances the spicy character while orange prevents the mixture from becoming excessively sharp.
๐ฒ Lemongrass and Cedarwood Blend
For something earthier:
- 2 drops lemongrass
- 3 drops cedarwood
- 2 drops frankincense
- 1 drop bergamot
Cedarwood and frankincense provide depth while lemongrass brings brightness.
This is particularly useful if you enjoy lemon aromas but prefer fragrances that are less obviously fruity.
โ๏ธ Bright Morning Blend
Try:
- 2 drops lemongrass
- 3 drops grapefruit
- 2 drops bergamot
This creates a fresh, lively fragrance ideal for a morning routine.
A pleasant aroma may make a room feel invigorating, but lemongrass should not be treated as a substitute for addressing persistent fatigue or other health concerns.
๐ Lemongrass and Relaxation
The sharp citrus-herbal aroma of lemongrass may not seem like an obvious relaxation fragrance, but some people find it refreshing and calming.
A recent randomized clinical trial examined inhaled lemongrass aroma among patients undergoing periodontal scaling and root planing.
Participants exposed to lemongrass aromatherapy experienced reductions in anxiety scores, heart rate, and blood-pressure measurements compared with controls.
That is an interesting clinical finding, but one study is not enough to establish lemongrass as a treatment for anxiety disorders.
For home aromatherapy, it is more reasonable to use the oil because you enjoy its fragrance.
๐ Softer Evening Blend
If straight lemongrass feels too bright for nighttime, surround it with gentler aromas.
Try:
- 1 drop lemongrass
- 3 drops lavender
- 2 drops frankincense
- 2 drops cedarwood
Using only one drop allows the citrus note to lift the blend without dominating it.
๐ฆ Antibacterial Research
Lemongrass has a long history of laboratory research into antimicrobial properties.
An early study examining C. citratus oil found antibacterial activity associated particularly with geranial and neral.
Researchers have since investigated activity against numerous microorganisms.
More recent laboratory work has also examined effects involving:
- Bacterial growth
- Dental organisms
- Biofilms
- Foodborne microorganisms
These findings make lemongrass scientifically interesting, but they should not be exaggerated into claims that a homemade diffuser or spray can prevent or cure bacterial infections.
๐ Antifungal Research
Antifungal activity is another major area of investigation.
Laboratory studies have found that Cymbopogon citratus oil can inhibit various fungi and yeasts under experimental conditions.
One study tested the oil against fungi including:
- Aspergillus niger
- Fusarium oxysporum
- Penicillium roquefortii
and several yeast species.
The oil inhibited fungal growth under laboratory conditions.
Other studies have examined lemongrass and citral against Candida species, including drug-resistant organisms.
These results are promising for scientific research but do not prove that applying a homemade essential oil preparation is a safe treatment for a fungal infection.
๐งซ Lemongrass and Candida Research
Candida research is frequently mentioned in discussions of this oil.
Laboratory experiments have found activity against Candida albicans and other Candida species.
A 2026 study also investigated C. citratus oil against organisms including Candida auris, an emerging drug-resistant fungal pathogen.
The tested oil was rich in geranial and neral and showed antifungal effects under experimental conditions.
This should not be interpreted as advice to self-treat a vaginal, oral, skin, or systemic fungal infection with concentrated oil.
Laboratory susceptibility testing and actual medical treatment are very different things.
๐ซ Don’t Use Lemongrass as a DIY Infection Treatment
The phrase “antimicrobial essential oil” can easily become misleading.
An oil that inhibits microorganisms in a laboratory dish may require concentrations that are irritating or unsuitable for human tissues.
Professional treatments also have established:
- Doses
- Delivery methods
- Safety profiles
- Quality controls
- Clinical evidence
Persistent bacterial or fungal infections deserve appropriate diagnosis and treatment.
Essential oils should not delay medical care.
๐ฟ Anti-Inflammatory Research
Researchers have also investigated potential anti-inflammatory activity.
One study found topical and oral anti-inflammatory effects in animal models while also documenting substantial antifungal activity.
That work is interesting, but animal experiments do not establish that applying diluted lemongrass to a sore knee treats arthritis or another inflammatory disorder in humans.
Many online articles blur the distinction between:
- Laboratory research
- Animal experiments
- Human clinical trials
Keeping those categories separate produces much more reliable aromatherapy information.
๐ Using Lemongrass in Massage Blends
Its fresh, spicy-citrus fragrance can work well in massage products, especially when balanced with gentler oils.
Try pairing it with:
- Lavender
- Frankincense
- Geranium
- Ginger
- Cedarwood
Possible carriers include:
- Jojoba
- Fractionated coconut oil
- Kukui nut oil
- Grapeseed oil
- Sweet almond oil
Because lemongrass is rich in citral and can irritate sensitive skin, conservative dilution is particularly important.
โ ๏ธ Why Dilution Matters
Lemongrass is not an oil I would use casually at high topical concentrations.
Citral is a known fragrance allergen and can contribute to:
- Irritation
- Redness
- Sensitization
- Allergic contact dermatitis
This does not mean everyone will react.
It means there is no benefit in turning a pleasantly scented body oil into an unnecessarily concentrated formula.
Follow reputable product-specific dilution guidance.
๐งด Lemongrass in Skin-Care Products
The oil appears in soaps, lotions, cleansers, and other cosmetics.
Its main practical role in ordinary home skin care is fragrance.
You may encounter claims that lemongrass:
- Eliminates acne
- Shrinks pores
- Removes wrinkles
- Tightens skin
- Cures fungal infections
- Controls oily skin
Strong human clinical evidence supporting these sweeping claims is limited.
A properly formulated cosmetic can smell wonderful without needing to double as a medical treatment.
๐ซ Don’t Apply It Undiluted to Acne
Laboratory antibacterial activity sometimes leads to recommendations to place concentrated lemongrass directly on pimples.
That is not a sensible tradeoff.
Irritating already-inflamed skin can make redness and discomfort worse.
For persistent acne, established treatments such as appropriately used benzoyl peroxide, salicylic acid, retinoids, or professional dermatological care have far stronger clinical support.
Enjoy lemongrass in appropriately formulated products rather than treating it as a spot medication.
๐ธ Using Lemongrass in Natural Perfume
Lemongrass can bring a sharp citrus-green top note to perfume.
It blends particularly well with:
Citrus:
Lemon, bergamot, grapefruit, sweet orange
Florals:
Geranium, lavender, ylang ylang
Herbs:
Clary sage, rosemary
Spices:
Ginger, coriander, cardamom
Woods:
Cedarwood, sandalwood
Resins:
Frankincense, benzoin
Because it is powerful, use less lemongrass than many of the surrounding ingredients.
๐บ Lemongrass and Ylang Ylang
For a tropical fragrance combination:
- 1 drop lemongrass
- 1 drop ylang ylang
- 3 drops sweet orange
- 2 drops sandalwood
Both lemongrass and ylang ylang can dominate blends, so small amounts work best.
The result combines tropical flowers, citrus, green herbs, and warm wood.
๐ฟ Lemongrass and Coriander
Coriander softens lemongrass beautifully.
Try:
- 2 drops lemongrass
- 2 drops coriander
- 3 drops bergamot
Coriander adds gentle spice and floral warmth while bergamot reinforces the fresh citrus quality.
๐งผ Lemongrass for Home Fragrance
Few oils smell as instantly fresh as lemongrass.
For a simple room fragrance, combine it with:
- Lemon
- Lavender
- Bergamot
- Rosemary
- Geranium
- Cedarwood
It can make kitchens and entryways smell particularly crisp.
Remember that making a room smell clean and actually cleaning it are separate things.
๐งฝ Lemongrass in Natural Cleaning Recipes
Because of its fragrance and laboratory antimicrobial research, lemongrass frequently appears in homemade cleaners.
It can be a lovely aromatic addition.
However, a DIY recipe containing lemongrass should not automatically be described as a disinfectant.
For everyday household cleaning, ingredients such as soap and appropriate detergents can physically remove dirt and grease.
For situations requiring reliable disinfection, use a product formulated and tested for that purpose.
๐ฆ Does Lemongrass Repel Mosquitoes?
Cymbopogon plants have attracted substantial research interest as sources of insect-repellent compounds.
Citral-rich lemongrass and related grasses may demonstrate repellent activity in experimental formulations.
However, the protection provided by a casual homemade essential oil blend may be shorter-lived and less reliable than established insect repellents.
When avoiding mosquito bites is important because of diseases such as West Nile, dengue, malaria, or Zika, use a repellent with demonstrated effectiveness and follow public-health recommendations.
A pleasant lemongrass patio fragrance should not be confused with guaranteed disease-vector protection.
๐ฟ Lemongrass vs. Citronella for Bugs
Citronella is generally more strongly associated with insect-repellent products.
Both come from closely related grasses, but their chemical profiles differ.
Rather than asking which oil “kills mosquitoes,” it is more useful to think about tested formulations.
How well an insect repellent performs depends on:
- Concentration
- Formulation
- Evaporation rate
- Application method
- Insect species
- Duration of exposure
The essential oil name alone cannot predict protection.
๐ Using Lemongrass in Bath Products
Do not simply drip concentrated lemongrass into bathwater.
Essential oils do not dissolve evenly in water.
Droplets can remain floating on the surface and make concentrated contact with skin.
That is particularly undesirable with a citral-rich oil capable of irritation.
Use a properly formulated bath product containing an appropriate dispersing or solubilizing system.
๐ Lemongrass for Hair and Scalp
Lemongrass sometimes appears in shampoos and scalp treatments because of its fresh fragrance and laboratory antimicrobial research.
Claims include:
- Controlling dandruff
- Reducing scalp oil
- Stimulating hair growth
- Treating scalp fungus
Evidence for some of these uses remains limited or formulation-specific.
A professionally formulated shampoo containing lemongrass is also very different from rubbing concentrated essential oil into the scalp.
If dandruff, itching, scaling, sores, or hair loss persists, identifying the underlying cause is more useful than continually adding aromatic oils.
๐ Can You Ingest Lemongrass Essential Oil?
Lemongrass is widely used as a culinary herb and as an herbal tea.
That does not make concentrated essential oil equivalent to a cup of lemongrass tea.
A tea contains water-soluble plant constituents at relatively low concentrations.
The essential oil is a concentrated mixture of volatile aromatic compounds.
For ordinary aromatherapy, there is no need to swallow it.
Use culinary lemongrass when you want the plant in food or beverages.
๐ต Lemongrass Tea vs. Essential Oil
The difference is worth emphasizing because the plant has substantial traditional medicinal use.
Lemongrass tea is prepared by steeping plant material in water.
Essential oil is obtained by distillation and contains concentrated volatile compounds.
Studies performed on tea, water extracts, alcoholic extracts, or isolated plant chemicals should not automatically be presented as evidence for the essential oil.
The preparation matters.
๐ How to Choose a Good Lemongrass Oil
Look for the botanical name:
Cymbopogon citratus
Also check:
- Plant part
- Extraction method
- Country of origin
- Ingredient list
- Batch or lot number
- Safety guidance
If the bottle lists Cymbopogon flexuosus, you have a related East Indian lemongrass oil rather than C. citratus.
That is not necessarily inferiorโit is simply a different species.
Clear labeling allows you to know what you are actually using.
๐งด How to Store Lemongrass Oil
Store the bottle:
- Tightly capped
- In dark glass
- Away from direct sunlight
- Away from excessive heat
- Out of children’s reach
Exposure to heat, oxygen, and light gradually changes essential oil chemistry.
Oxidized aromatic products may be more likely to irritate sensitive skin.
Avoid keeping essential oils on sunny bathroom shelves, windowsills, or in hot vehicles.
โ ๏ธ Lemongrass Essential Oil Safety
Lemongrass is strongly aromatic and deserves conservative topical use.
Keep these precautions in mind:
- Dilute before applying to skin.
- Avoid undiluted topical use.
- Keep away from the eyes and mucous membranes.
- Stop use if burning, redness, itching, or swelling occurs.
- Do not put concentrated oil into bathwater.
- Keep bottles securely away from children.
- Avoid routine DIY ingestion.
- Use reasonable amounts when diffusing.
- Provide ventilation.
- Follow product-specific dilution and safety instructions.
People with fragrance allergies, eczema, or especially reactive skin may be more susceptible to irritation.
๐คฐ Lemongrass During Pregnancy
Reliable human safety data for concentrated therapeutic use during pregnancy are limited.
Pregnancy is therefore a sensible time to use essential oils conservatively.
Occasional ambient fragrance is different from:
- Repeated high-dose diffusion
- Extensive topical application
- Internal use
If you want to use lemongrass regularly during pregnancy, particularly for a specific symptom, discuss it with an appropriate maternity healthcare professional.
๐ถ Lemongrass Around Children
The fresh lemon scent can make lemongrass seem gentle, but it remains concentrated.
Keep bottles where children cannot open or swallow them.
When diffusing in a shared space:
- Use small amounts.
- Provide good ventilation.
- Avoid continuous diffusion.
- Keep the diffuser out of reach.
- Follow age-appropriate guidance.
Children generally require much less fragrance exposure than adults.
๐ถ Lemongrass Around Pets
Concentrated aromas should also be used carefully around animals.
When diffusing lemongrass:
- Use modest amounts.
- Ventilate the room.
- Allow pets to leave the area.
- Keep bottles and diffusers inaccessible.
- Clean spills promptly.
- Do not apply concentrated oil directly to animals.
Birds, cats, very young pets, and animals with respiratory problems may require additional caution.
Consult a veterinarian before using concentrated essential oils therapeutically on a pet.
โ Frequently Asked Questions
What is lemongrass essential oil used for?
It is commonly used in diffusers, soaps, massage products, natural perfume, home fragrance, and cleaning blends. Researchers have also studied its antimicrobial, antifungal, anti-inflammatory, and possible anxiolytic effects.
What does lemongrass smell like?
It smells intensely lemony, grassy, fresh, green, and herbal.
What is the main compound in lemongrass oil?
Citral is responsible for much of the aroma. Citral consists primarily of two related compounds: geranial and neral.
Is lemongrass the same as lemon?
No. Lemongrass is a tropical grass in the genus Cymbopogon. Lemon is a citrus tree in the genus Citrus.
Is lemongrass the same as citronella?
No, although the plants are closely related. Both belong to the genus Cymbopogon, but commercial citronella generally comes from other species.
Is lemongrass antibacterial?
Laboratory studies have demonstrated antibacterial activity from the oil and its citral constituents against certain microorganisms. This does not make homemade lemongrass products substitutes for antibiotics or validated disinfectants.
Is lemongrass antifungal?
The oil has demonstrated antifungal activity against numerous fungi and yeasts under laboratory conditions. Clinical evidence for treating human fungal infections with homemade preparations is much more limited.
Can lemongrass help anxiety?
A recent randomized clinical trial reported reductions in anxiety measures among dental patients inhaling lemongrass aroma. More research is needed before it can be considered a treatment for anxiety disorders.
Can you put lemongrass directly on your skin?
Routine undiluted use is not recommended. Its high citral content can contribute to irritation and sensitization, so appropriate dilution is important.
Does lemongrass repel mosquitoes?
Lemongrass and related Cymbopogon oils have demonstrated repellent properties in experimental research. For reliable protection against mosquito-borne disease, use proven repellent products rather than relying exclusively on homemade essential oil blends.
Can I diffuse lemongrass?
Yes. Because its fragrance is strong, one or two drops may be enough when combined with softer oils such as lavender, orange, geranium, or cedarwood.
What blends well with lemongrass?
Lemon, bergamot, grapefruit, sweet orange, lavender, geranium, ginger, coriander, frankincense, cedarwood, and ylang ylang all pair well with its citrus-herbal aroma.
Can you drink lemongrass essential oil?
Routine DIY ingestion is unnecessary. Culinary lemongrass or properly prepared lemongrass tea is very different from concentrated volatile oil.
โจ Final Thoughts
Lemongrass essential oil combines the bright familiarity of lemon with the green, earthy character of a tropical grass.
Its high concentrations of geranial and neral create an extraordinarily vivid citrus fragrance that can transform diffuser blends, home fragrance, perfume, soaps, and massage products with only a small amount.
The oil is also scientifically interesting. Laboratory studies have repeatedly demonstrated antibacterial and antifungal activity, and researchers continue to investigate citral-rich lemongrass against challenging organisms and biofilms. A recent human clinical trial has even reported promising results for inhaled lemongrass aroma during anxiety-provoking dental treatment.
Those findings are worth following, but they do not turn the oil into a substitute for antibiotics, antifungal medication, anxiety treatment, or proven insect repellents.
For everyday aromatherapy, its fragrance is more than enough.
Pair it with lavender for softness, geranium for a floral botanical blend, ginger for warmth, citrus oils for extra brightness, or cedarwood and frankincense for a deeper aroma.
Just remember that the same citral content responsible for that beautiful lemon scent also makes careful topical dilution important.
Used thoughtfully, lemongrass is one of the freshest and most distinctive aromatic grasses available.
๐ Related Articles
- Lemon Essential Oil
- Ginger Essential Oil
- Geranium Essential Oil
- Coriander Essential Oil
- Frankincense Essential Oil
- Juniper Berry Essential Oil
- Types of Essential Oil Diffusers: How to Choose the Best One
- DIY Reed Diffuser: How to Make a Natural Essential Oil Diffuser
- Essential Oil Blending Secrets: Create Perfect Combinations Every Time
๐ Sources & Further Reading
- Royal Botanic Gardens, Kew โ Cymbopogon citratus
- PubMed โ Antibacterial Constituents in the Essential Oil of Cymbopogon citratus
- PubMed โ Effectiveness of Cymbopogon citratus Essential Oil Against Filamentous Fungi and Yeasts
- PubMed โ Lemongrass Essential Oil as a Potent Anti-Inflammatory and Antifungal Agent
- PubMed โ Liquid and Vapour-Phase Antifungal Activity of Cymbopogon citratus
- PubMed โ Anti-Candida Activity of Lemongrass Oil and Citral
- PubMed โ Cymbopogon citratus Essential Oil and Polymicrobial Dental Biofilm
- PubMed โ Antifungal Properties of Essential Oils Derived From the Genus Cymbopogon: A Systematic Review
- PubMed โ Effect of Lemongrass Aromatherapy on Anxiety During Periodontal Treatment
- PubMed โ Characterization and Antifungal Activity of Cymbopogon citratus Against Candida auris and Cryptococcus neoformans